Monograph: |
Ethacridine Lactate
The acridine derivatives are slow-acting antiseptics. They are
bacteriostatic against many Gram-positive bacteria but less
effective against Gram-negative bacteria. They are ineffective
against spores. Their activity is increased in alkaline solutions
and is not reduced by tissue fluids.
The acridine derivatives have been used for the treatment of
infected wounds or bums and for skin disinfection although
they have been largely Superseded by other antiseptics or suit-
able antibacterials. Prolonged treatment may delay
healing. They have also been used for the treatment of local
ear, oropharyngeal, and genito-urinary infections.
Aminacrine hydrochloride which is reported to be non-stain-
ing has been used most recently as eye drops in the treatment
and prophylaxis of superficial eye infections.
Ethacridine lactate has been included in some preparations
for the treatment of diarrhoea. It has also been given by extra-
amniotic injection for the termination of pregnancy but other
methods are usually preferred. An injection of 100-150 ml of
solution is given by plain catheter extra-amniotically over 10
mts. which is then clamped and left for 2-6 hrs.
During this period uterine contractions can take place which
expel the products or i.v. oxytocin drip can be started to induce
uterine contractions. If this method fails then other methods
should be tried.
Hypersensitivity to acridine derivatives has been reported.
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